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Week 4's Injury Fallout: Lamar in a Boot, Cincinnati Lost Both Receivers, and Philly's Backfield Got Hit Twice

Lamar Jackson left in a walking boot, the Bengals lost Ja'Marr Chase and Tee Higgins in the same game, Kansas City lost two receivers in three quarters, and the Eagles lost Saquon Barkley and then his backup. The full damage report, and who inherits the work.

LeagueLocksBy Nolan Gaffney · Founder, LeagueLocks · Oct 6, 2026 · 8 min read

Week 4's Injury Fallout: Lamar in a Boot, Cincinnati Lost Both Receivers, and Philly's Backfield Got Hit Twice - cover artInjury Report

Week 2 took the quarterbacks. Week 4 came for everyone else. By Sunday night the casualty list read like a fantasy draft's second round: an MVP quarterback in a walking boot, both Cincinnati starting receivers, two Kansas City receivers, and both halves of Philadelphia's backfield. SI's injury roundup and Forbes' Monday report have the full list. Here is what each one actually changes.

Lamar Jackson, ankle: the one that moves a line

Jackson was having one of his cleanest halves of the season against Tennessee, 15 of 20 for 222 yards and two scores, when a sack ended his day. He left in a protective boot, the follow-up imaging was still pending Monday, and the only official word is day-to-day, with his coach openly unsure about Week 5 at Atlanta. Tyler Huntley closed out the 24-18 win by completing 8 of 9 in relief. The fantasy read: hold and watch Wednesday's practice report. The betting read: Baltimore at Atlanta opened with the Falcons laying 3, and that number is a hostage to one MRI. If your league is eyeing anything in that game, wait for the designation before you vote, the same rule from our injury-report framework.

Philadelphia's double hit

Saquon Barkley's hamstring ended his afternoon on the second drive against the Rams, and the early reporting says it is not considered serious, though hamstrings keep their own calendar. The crueler twist came in the fourth quarter: Tank Bigsby, the handcuff who we told you in September spikes in value exactly once, got his spike, ran 14 times for 55 yards, and then was carted off with a core muscle injury that needs surgery and lands him on injured reserve for at least a month. One game, both backs. Will Shipley is the last man standing in that backfield, and he is the headline of this week's waiver column. With DeVonta Smith's hamstring already keeping him out and Jalen Hurts throwing for 93 yards in a 24-20 home loss, Philadelphia's offense is in genuine trouble.

Cincinnati lost both, in the same loss

Ja'Marr Chase got yanked down by the facemask in the second quarter and left with a concussion after just 3 targets. Tee Higgins picked up the slack spectacularly, 11 catches for 157 yards on 16 targets, and then strained an adductor on the final drive. The early word on both is encouraging, Chase is not expected to be out long and Higgins is day-to-day, but the Bengals lost to Jacksonville 22-17 at home with Joe Burrow throwing 54 times for 428 yards, and they visit Miami next with a receiver room held together by Dohnte Meyers and tape. Meyers caught 7 of 9 targets for 82 yards stepping in, and he is this week's clearest volume inheritance.

Kansas City won the game and lost the receiver room

The Chiefs escaped Las Vegas 30-27 to reach 4-0, and paid retail for it. Rashee Rice pulled up with a non-contact hamstring midway through the first quarter, the kind of injury trainers hate most, with reports split between weeks and days. Then Tyquan Thornton, who had stepped up with 5 catches for 111 yards and two touchdowns including a 55-yard go-ahead score, dislocated an ankle in the fourth quarter and was carted off. Forbes pegs his timeline at 12 to 16 weeks, which is a season in all but name. The schedule's one mercy is the Week 5 bye. Xavier Worthy, 4 catches for 70 yards Sunday, becomes the clear top target whenever football resumes in Kansas City.

Washington's carousel spins again, maybe toward good news

Marcus Mariota sprained an MCL against the Colts, aggravating a camp injury, and is expected to miss time; third-stringer Athan Kaliakmanis finished the 30-13 loss. The actual headline is the other direction: Jayden Daniels, whose dislocated elbow we covered when it happened in Week 2, is hoping to return for Week 5 against the Giants with a full practice week planned. If he is back, every Washington pass catcher gets a projection bump, and the Commanders stop being an automatic fade.

The rest of the ledger

Buffalo's DJ Moore aggravated the shoulder from Week 2 and could not return; it is reportedly not a long-term issue, but Keon Coleman's 116-yard audition in his absence makes that rotation worth watching either way. Ladd McConkey aggravated a foot injury and finished with zero catches in the Chargers' 30-23 loss in Seattle. Denver rookie Pat Bryant is expected to miss a few weeks with an ankle sprain. And the returns column is finally filling up: Justin Jefferson has made what Minnesota calls great progress on his ankle and is hopeful for Week 5 in New Orleans, where T.J. Hockenson's 13-target afternoon showed exactly how much vacuum Jefferson leaves behind.

What it means when your league picks this week

Same framework as always, with one Week 4 addendum. The market reprices star injuries within hours, so the value is never in simply fading Baltimore or Philadelphia; it lives in the props and totals that lag the spread. Next-man-up receivers like Meyers and Coleman get soft prop numbers for exactly one week before the books catch up. And if your league is voting on anything involving the Ravens, Bengals, or Eagles, wait for Wednesday's practice designations. One injury report line will move those games more than anything in a box score, as our betting ledger keeps proving.

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Sources are linked where they're used in the article above. Stats and lines are as reported by the cited outlets at publish time. LeagueLocks is not affiliated with the NFL or any team.

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